Translational Product Development Fund

Close-up image of multiple vials and a syringe filling one of the vials

The Translational Product Development Fund (TPDF) supports the advancement of projects that have the potential to be commercialized, such as projects that aim to form a start-up company or create a license agreement with an established commercial entity. 

Dates and deadlines

Cycle 1

  • Applications due 11:59pm, March 3, 2021
  • Review period: March - June
  • Earliest project start date: July 1 

Cycle 2

  • Applications due 11:59pm, June 9, 2021
  • Review period: June - September
  • Earliest project start date: October 1 

Cycle 3

  • Applications due 11:59pm, September 8, 2021
  • Review period: September - December
  • Earliest project start date: January 1, 2022

About the program

CTSI and the Mayo Clinic Center for Clinical and Translational Science (CCaTS) established TPDF in conjunction with the Minnesota Partnership for Biotechnology and Medical Genomics (MNP).

Ultimately, the program aims to impact the lives of Minnesotans by translating research discoveries into new therapies and treatment approaches for patients.

How we can help


New awards

David Haynes, PhD and Pinar Karaca-Mandic, PhD (UMN)
Project title: Smart Community Health

Huber Lim, PhD (UMN)
Project title: Enhancing Hearing Using Noninvasive Bimodal Neuromodulation with Novel "Ampear Buds" Technology

Timothy O'Brien, DVM, PhD (UMN)
Project title: iPSC Derived Cartilage Cells for Treatment of Osteoarthritis

Mukesh Pandey, PhD, Aditya Bansal, PhD, Sean Park, MD, PhD, and Haidong Dong, MD, PhD (Mayo Clinic)
Project title: Design, Synthesis and Preliminary Evaluation of B-11 Antibody Fragments for PD-L1 PET Imaging

Rita Perlingeiro, PhD (UMN)
Project title: Delivery Optimization of MayoPaxon in Non-human Primates

Elizabeth Rajan, MD (Mayo Clinic)
Project title: Flexible Tube-assist Balloon Dilator with Camera: Self-dilation of Benign Esophageal Strictures


Cycle 7

Rumi Faizer, MD and Victor Barocas, PhD (UMN) 

Project title: A Compliant Stent-graft to Lower Blood Pressure in Patients with Aortic Disease

Richard Vile, PhD (Mayo Clinic) and Ruben Harris, PhD (UMN)

Project title: Translation of an APOBEC3B-modified vaccine, in combination with checkpoint inhibition, for the treatment of adult human, and companion animal canine, glioblastoma

Luis Savastano, MD, PhD (Mayo Clinic)

Project title: Minimally Invasive Drainage of Subdural Hematomas


Cycle 6

Andres Acosta, MD, PhD, Mayo Clinic

Project Title: Development of Selective Ileo-Colonic Bitter Taste 2 Receptor 5 Agonist for Treatment of Obesity and Type 2 Diabetes

Michael Barry, PhD, Mayo Clinic, and Alexander Khoruts, MD, University of Minnesota

Project title: Vaccines to Combat Clostridioides (Clostridium) Difficile

Arthur Erdman, PhD, Ahmed Selim, MD

Project title: Translational Development of a Targeted Cardiocerebral Extracorporeal Membrane Oxygenation (TC-ECMO) System 

Alan Marmorstein, PhD, Mayo Clinic

Project title: Stem Cell Derived RPE for Treatment of Macular Degeneration


Cycle 5

Nicholas LaRusso, MD and Tatyana Masyuk, PhD (co-PI), Mayo Clinic

Project title: In vitro and in vivo testing the effects of SBI 319, a novel TGR5 antagonist, in treatment of the cholangiopathies

Samuel Asirvatham, MD, Mayo Clinic

Project title: Epicardial pacing and defibrillation with a novel percutaneously implanted transverse sinus device

Roy Cho, MD, MHA, University of Minnesota

Project title: Multi-compartment syringe for endobronchial ultrasound transbronchial needle aspiration


Cycle 4

Andreas Beutler, MD, Mayo Clinic, Rochester and James Collins, DVM, PhD, Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota

Project title: Intraganglionic Treatment for Chronic Locoregional Pain

Arthur Erdman, PhD, Medical Devices Center, College of Science and Engineering, and Courtney Hill, MD, Medical Devices Center, Institute for Engineering in Medicine, University of Minnesota

Project title: Optimizing Infant Nutrition with Breastmilk Device

D. Dean Potter, MD, Dennis Wigle MD, PhD, and Stephanie Polites, MD, Mayo Clinic, Rochester

Project title: Development of a Neonatal Esophageal Lengthening and Anastomotic Device

Martin Zielinski, MD, and Jonathan M. Aho, MD, Mayo Clinic, Rochester

Project title: Treatment of Tension Pneumothorax Decompression with Needle Thoracostomy Colorimetric Capnography


Cycle 3

Grace Lin, MD, Mayo Clinic, and Paul Friedman, MD, Mayo Clinic

Project title: Ambulatory Noninvasive Measurement of Potassium in Patients with Cardiac and Renal Disease to Prevent Rehospitalization

Gregory J. Beilman, MD, Medical School, Department of Surgery, University of Minnesota

Project title: Preclinical Development of Beta-hydroxybutyrate/Melatonin (BHB/M) for the Treatment of Trauma-induced Acute Blood Loss


Cycle 1

Samuel Asirvatham, MD, Department of Medicine and Pediatrics, Mayo Clinic, and David R. Holmes, Jr., MD, MaCC, Department of Medicine, Mayo Clinic

Project title: Combination Radiofrequency and Electroporation Energy for Balloon-Based Ablation and Drug Delivery: A Novel Treatment Modality for Atrial Fibrillation

Barry Borlaug, MD, Department of Medicine/Cardiovascular Diseases, Mayo Clinic

Project title: Minimally Invasive Pericardial Resection to Treat Heart Failure

Sven-Ulrik Gorr, PhD, College of Dentistry, Department of Diagnostic and Biological Sciences, University of Minnesota

Project title: A Novel Antimicrobial Peptide for Drug-resistant Bacterial Infections

Valerie Pierre, PhD, College of Science & Engineering, Department of Chemistry, University of Minnesota and Robin Patel, MD, Department of Medicine, Mayo Clinic

Project title: Novel Biotechnology for Rapid, Point-of-Care Diagnosis of Bacterial Infection

David Potter, MD, Medical School, Department of Medicine, University of Minnesota, and Robert Schumacher, PhD, Center for Translational Medicine, University of Minnesota

Project title: Development of Hexyl-Benzyl-Biguanide for Breast Cancer Therapeutics

Cycle 2

Kenneth Beckman, PhD, and Daryl Gohl, PhD,  University of Minnesota Genomics Center, University of Minnesota

Project title: Micrometer: Next-generation Standards for Microbiome Analysis

Kathleen A. Harder, PhD, University of Minnesota Center for Design in Health, and Ognjen Gajic, MD, MS,  Department of Pulmonary and Critical Care Medicine, Mayo Clinic

Project title: Pilot Implementation of Cloud-based Electronic Checklist to Improve Daily ICU Rounds in Rural Access Hospitals

Steven Koester, PhD, College of Science and Engineering, Department of Electrical and Computer Engineering, University of Minnesota, and Bruce Gerbi, PhD, Medical School, Department of Therapeutic Radiology-Radiation Oncology, University of Minnesota

Project title: Development of Ultrasmall Wireless Radiation Sensors for In Vivo dosimetry in Cancer Therapy

Gregory J. Beilman, MD, Medical School, Department of Surgery, University of Minnesota, and David Morris, MD, Department of Trauma, Critical Care and General Surgery, Mayo Clinic

Project title: Fiber-optic Tube Thoracostomy Trocar for Improved Patient Chest Drainage


Sandra Wells, PhD
Assistant Director
Office of Discovery and Translation
[email protected]

Roberto Zayas Nazario, PhD
Office of Translation to Practice, Mayo Clinic
[email protected]